Modimolle (previously Nylstroom) is a town located near the southern edge of the Waterberg Massif in Limpopo province, South Africa. It is a medium sized town that focuses primarily on agriculture and farming (citrus, grapes and cattle) as well as wildlife and tourism. Nylstroom/Modimolle is also located approximately 135 kilometres north of Pretoria, South Africa's de facto capital city.
The Waterberg Biosphere spreading north, a UNESCO designated Biosphere Reserve, contains approximately 15,000 square kilometers. Waterberg is the first region in the northern part of South Africa to be named as a Biosphere Reserve by UNESCO. The extensive rock formation was shaped by hundreds of millions of years of riverine erosion to yield diverse bluff and butte landform. The ecosystem can be characterised as a dry deciduous forest or Bushveld.
The South African government officially changed the name of the town to Modimolle in 2002. The name comes from the Tswana phrase, Modimo o lle, meaning "the forefather's spirit has eaten", or "God has eaten".